scholarly journals Radioactive phosphorus (P32) studies in transplanted carcinoma.II. Total P32 turnover in transplanted mammary carcinoma, inflammatory granuloma, and normal stomach tissue of ZBC mice

Cancer ◽  
1959 ◽  
Vol 12 (5) ◽  
pp. 966-969
Author(s):  
Donald B. Shahon
Keyword(s):  
Mammary Carcinoma ◽  
Radioactive Phosphorus ◽  
Stomach Tissue ◽  
Inflammatory Granuloma ◽  
Normal Stomach

Creatine kinase and lactate dehydrogenase isoenzymes in serum and tissues of patients with stomach adenocarcinoma.

1989 ◽  
Vol 35 (7) ◽  
pp. 1385-1389 ◽  
Author(s):  
R D Hirata ◽  
M H Hirata ◽  
B Strufaldi ◽  
R A Possik ◽  
M Asai
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Gastric Resection ◽  
Tissue Samples ◽  
Stomach Tissue ◽  
Stomach Adenocarcinoma ◽  
Normal Stomach ◽  
Lactate Dehydrogenase Isoenzymes

Abstract Total activities of creatine kinase (EC 2.7.3.2; CK) and lactate dehydrogenase (EC 1.1.1.27; LD) and their isoenzymes were estimated in serum and tissue samples from patients with stomach adenocarcinomas who were to undergo gastric resection. Total CK activity (U/g protein) appeared to be markedly decreased in neoplastic stomach tissue. CK-BB was the predominant isoenzyme in both neoplastic and normal stomach tissues; however, the CK-BB/total CK ratio was increased in adenocarcinoma tissue. Macro CK type 1 was found in two neoplastic tissues and macro CK type 2 in 11. LD4 and LD5 isoenzymes were predominant in gastric tissues, but LD5 and the LD5/LD1 ratio were higher in adenocarcinoma tissue. At 24 h before surgery, CK-BB was demonstrated in sera of all patients and CK-MB in 69%. The CK-BB probably originated from neoplastic stomach tissue, which contains high CK activity, with BB isoenzyme predominating. After gastrectomy, CK and LD isoenzymes in sera were markedly increased by 24 h postsurgery. These alterations were attributed to release from damaged tissue during gastric resection.

Basal Lamina Formation in DMBA Induced Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 534-535
Author(s):  
I. Russo ◽  
J. Saby ◽  
J. Russo
Keyword(s):  
Mammary Carcinoma ◽  
Virgin Female ◽  
Mammary Glands ◽  
Sesame Oil ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Intermediate Type ◽  
Sprague Dawley ◽  
Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

The Ultrastructure of Metastatic Human Mammary Carcinoma After Prolonged Estrogen Therapy

1967 ◽  
Vol 25 ◽  
pp. 180-181
Author(s):  
John H.L. Watson ◽  
John L. Swedo ◽  
R.W. Talley
Keyword(s):  
Mammary Carcinoma ◽  
Osmium Tetroxide ◽  
Estrogen Therapy ◽  
Ultrastructural Level ◽  
Uranyl Acetate ◽  
Human Mammary Carcinoma ◽  
Surgical Biopsy ◽  
Lead Hydroxide ◽  
Preliminary Study ◽  
Hormonal Therapies

A preliminary study of human mammary carcinoma on the ultrastructural level is reported for a metastatic, subcutaneous nodule, obtained as a surgical biopsy. The patient's tumor had responded favorably to a series of hormonal therapies, including androgens, estrogens, progestins, and corticoids for recurring nodules over eight years. The pertinent nodule was removed from the region of the gluteal maximus, two weeks following stilbestrol therapy. It was about 1.5 cms in diameter, and was located within the dermis. Pieces from it were fixed immediately in cold fixatives: phosphate buffered osmium tetroxide, glutaraldehyde, and paraformaldehyde. Embedment in each case was in Vestopal W. Contrasting was done with combinations of uranyl acetate and lead hydroxide.

DETERMINATION OF THYROTROPHIN BY MEANS OF RADIOACTIVE PHOSPHORUS

1949 ◽  
Vol 3 (4) ◽  
pp. 331-341 ◽  
Author(s):  
ULF BORELL ◽  
HJALMAR HOLMGREN
Keyword(s):  
Radioactive Phosphorus

RENAL FUNCTION AND KIDNEY SIZE FOLLOWING HYPOPHYSECTOMY IN MAN

1965 ◽  
Vol 48 (3) ◽  
pp. 348-354 ◽  
Author(s):  
Thomas Falkheden ◽  
Ingmar Wickbom
Keyword(s):  
Renal Function ◽  
Diabetic Retinopathy ◽  
Glomerular Filtration Rate ◽  
Plasma Flow ◽  
Mammary Carcinoma ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Kidney Weight ◽  
Kidney Size ◽  
Before And After

ABSTRACT Measurements of glomerular filtration rate (GFR) and renal plasma flow (RPF) were performed in close connection with roentgenographic estimation of kidney size, before and after hypophysectomy, in 10 patients (four cases of metastatic mammary carcinoma, five cases of diabetic retinopathy and one case of acromegaly). Hypophysectomy was regularly followed by a decrease in GFR and RPF. In most cases, a reduction in the roentgenographic kidney size was also observed. However, the changes in the roentgenographic kidney size and calculated kidney weight after hypophysectomy were smaller and occurred at a slower rate than the alterations in GFR and RPF. The results favour the view that, primarily, the decrease in GFR and RPF following hypophysectomy is essentially functional rather than due to a reduced kidney mass.

THE EXCRETION OF PITUITARY GONADOTROPHINS, OESTROGENS, PREGNANEDIOL AND NEUTRAL 17-KETOSTEROIDS IN THE URINE OF PATIENTS WITH METASTATIC AND RECURRENT MAMMARY CARCINOMA

1957 ◽  
Vol 24 (3_Suppl) ◽  
pp. S273-S274 ◽  
Author(s):  
J. B. Brown ◽  
J. Bruce ◽  
Mary Douglas ◽  
A. Klopper ◽  
J. A. Loraine ◽  
...  
Keyword(s):  
Mammary Carcinoma

STUDIES ON SULFATION FACTOR (SF) ACTIVITY OF HUMAN SERUM

1961 ◽  
Vol 37 (2) ◽  
pp. 315-320 ◽  
Author(s):  
Sven Almqvist ◽  
Thomas Falkheden
Keyword(s):  
Human Serum ◽  
Mammary Carcinoma ◽  
Half Life

ABSTRACT Serum SF activity was followed after hypophysectomy in three patients with mammary carcinoma and after excision of an eosinophilic adenoma in two patients with acromegaly. Serum SF decreased within 12 hours of hypophysectomy and then fell exponentially with time to the usual post-hypophysectomy level. The half life of serum SF in the three patients undergoing hypophysectomy was 9, 10.5 and 18 hours.

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